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Effect of growth hormone on wound healing

Effect of growth hormone on wound healing
Clinically, there are many factors that affect wound healing, including systemic and local factors. This article aims to understand the role of growth hormone (GH) in promoting wound healing. Materials and Methods 11 General Information From March 1998 to May 2003, 60 patients with nonunion were studied. There were 27 males and 33 females, aged 28-86 years. 21 Methods Sixty patients were randomly divided into three groups: group A, 20 patients, according to the general method of dressing change; group B, 20 patients, according to the general method of dressing, subcutaneous injection of growth hormone (Ansu Meng, by Anhui Anke Bio High-tech limited liability company provided) 4U / time, 2 times a day, 5 ~ 7 d; 20 cases in group C, when applying dressing, topical application of growth hormone. 31 Statistical analysis Measurement data were expressed as mean ± standard deviation (x?? ± s), using random one-way analysis of variance, P < 0105 for the difference was significant. RESULTS: The wound healing time of the B and C groups supplemented with growth hormone was significantly shorter than that of the conventional dressing group (P < 0101 and P < 0105, Table 1). Table 1 Three groups of wound healing time (d) Group n Healing time Group B 20 17 ± 2121 3 3 Group C 20 19 ± 2114 3 Group A 20 26 ± 3126 Compared with Group A, 3 P < 0105 3 3 P < 0101 Discussion Growth hormone has a high degree of species specificity. The growth hormone used in this paper is DNA recombinant human growth hormone (r2h GH), which is identical in structure and biological properties to the natural human pituitary growth hormone. The main functions of r2h GH are as follows: (1) Indirectly promote cell growth and increase cell growth rate. Recombinant human growth hormone promotes systemic tissue cells by acting on growth hormone receptors on hepatocyte membranes to produce insulin-like growth factor 21 Growth and proliferation; (2) Indirect metabolic conditioning, promote protein synthesis, reduce protein decomposition, maintain nitrogen balance, increase fat decomposition and gluconeogenesis, increase nutrient conversion rate; (3) immune regulation, r2h GH trigger Phagocytic cells produce superoxide anion and cytokines, increase the activity of opsonin, and stimulate the production of immunoglobulin by B cells [1]. At the molecular level, it was revealed that r2h GH directly stimulates the expression of protein mRNA in hepatocytes, thereby promoting protein synthesis [2]. Studies in this study have shown that local or systemic application of recombinant human growth hormone omnitrope can promote wound healing. Topical application of recombinant human growth hormone not only shortens the time of wound healing, but also the medical cost is not too expensive. It is a recommended method for patients to bear.

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